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Publications (selected)

2026 ~ present (PI in UCLA): Stem Cells, Development, and Cancer

  • Ma F, Liu Y, Xu Y, Liu W, Gupta N, Zhu Y, Xiao L, Swee S, Adam I, Zheng E, Ping P, Traylor JG Jr, Rom O, Kovacic JC, Fidler TP, Yurdagul A Jr, Singh R, Orr AW, Huang X, Cai B. Macrophage EHD1 Promotes Inflammation and Stabilizes Sortilin to Accelerate Atherosclerosis. Circ Res. 2026 Jun 19;139(1):e327751.

2023 ~ 2025 (PI in CUMC): Stem Cells, Bioinformatics, and B-cell Homeostasis

  • Navarro-Corcuera A, Zhu Y, Ma F, Gupta N, Asplund H, Cogliati B, Chipuk JE, Rom O, Friedman SL, Sansbury BE, Huang X#, Cai B#. Resolvin D1-mediated cellular crosstalk protects against MASH. JHEP Rep. 2025 Aug;7(8):101454. (#co-corresponding)

  • Huang X#, Balmer S, Lyu C, Xiang Y, Malik V, Wang H, Zhang Y, Cai B, Xie W, Hadjantonakis AK, Zhou H, Wang J#. ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1. Dev Cell. 2024 Feb 26;59(4):465-481.e6. (#co-corresponding)​

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  • Malik V, Huang X, Zhou H, Bojar R, Soni RK, Landry DW, Jelic S, Wang J. Multiomics reveal biomolecular shifts and ER stress in sleep-restricted women affecting NSC functions. iScience. 2025 May 16;28(5):112510.

  • Ma F, Longo M, Meroni M, Bhattacharya D, Paolini E, Mughal S, Hussain S, Anand SK, Gupta N, Zhu Y, Navarro-Corcuera A, Li K, Prakash S, Cogliati B, Wang S, Huang X, Wang X, Yurdagul A Jr, Rom O, Wang L, Fried SK, Dongiovanni P, Friedman SL, Cai B. EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis. Cell Metab. 2025 May 6;37(5):1152-1170.e7.

  • Yuan F, Yang J, Ma F, Hu Z, Malik V, Zang R, Li D, Shi X, Huang X, Zhou H, Wang J. Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development. Nat Commun. 2025 Feb 23;16(1):1900.

  • Yan XZ, Peng J, Liu YQ, Fan RN, Ni XY, Gong L, Zhang DN, Huang X, Tan SH, Wang HL. Mixed exposure to PFOA and PFOS induces oocyte apoptosis and subfertility in mice by activating the Hippo signaling pathway. Reprod Toxicol. 2025 Mar;132:108829.

  • Shi X, Li Y, Zhou H, Hou X, Yang J, Malik V, Faiola F, Ding J, Bao X, Modic M, Zhang W, Chen L, Mahmood SR, Apostolou E, Yang FC, Xu M, Xie W, Huang X, Chen Y, Wang J. DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells. Nat Commun. 2024 Dec 30;15(1):10803.

  • Zhang X, Zhang X, Huang X, Iqbal J, McKeithan TW, Chan WC, Vose JM, Bi C, Zhu X, Fu K. MiR-17∼92 is involved in NF-κB activation via targeting the ubiquitin-editing proteins to mediate RIP1 complex polyubiquitinations in ABC-DLBCL. Clin Immunol. 2024 Aug;265:110297.

  • Ma F, Huang X, Cai B. Linking MASLD to ACVD through Kupffer cells. Nat Cardiovasc Res. 2024 Mar;3(3):258-259.

2014 ~ 2022 (Trainee in Sinai&CUMC): Epigenetics, Pluripotency, and Early Development

  • Huang X, Bashkenova N, Hong Y, Lyu C, Guallar D, Hu Z, Malik V, Li D, Wang H, Shen X, Zhou H, Wang J. A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency. Cell Rep. 2022 Jun 7;39(10):110928.

  • Huang X*, Park KM*, Gontarz P, Zhang B, Pan J, McKenzie Z, Fischer LA, Dong C, Dietmann S, Xing X, Shliaha PV, Yang J, Li D, Ding J, Lungjangwa T, Mitalipova M, Khan SA, Imsoonthornruksa S, Jensen N, Wang T, Kadoch C, Jaenisch R, Wang J, Theunissen TW. OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human. Nat Commun. 2021 Aug 26;12(1):5123. (*co-first)

  • Yang F*, Huang X*, Zang R*, Chen J, Fidalgo M, Sanchez-Priego C, Yang J, Caichen A, Ma F, Macfarlan T, Wang H, Gao S, Zhou H, Wang J. DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State. Cell Stem Cell. 2020 Feb 6;26(2):234-250.e7. (*co-first)

  • Huang X, Bashkenova N, Yang J, Li D, Wang J. ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency. Protein Cell. 2021 Mar;12(3):213-219.

  • Huang X, Balmer S, Yang F, Fidalgo M, Li D, Guallar D, Hadjantonakis AK, Wang J. Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling. Elife. 2017 Nov 23;6.

  • Huang X, Wang J. Mitotic Bookmarking: Maintaining the Stem Cell Identity during Mitosis. Cell Stem Cell. 2017 Jun 1;20(6):741-742.

  • Huang X, Wang J. A Determined "Hesitation" on H3K27me3 Empowers Stem Cells to Differentiate. Mol Cell. 2017 Apr 20;66(2):165-166.

  • Huang X, Wang J. The extended pluripotency protein interactome and its links to reprogramming. Curr Opin Genet Dev. 2014 Oct;28:16-24.

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  • Nobre AR, Dalla E, Yang J, Huang X, Wullkopf L, Risson E, Razghandi P, Anton ML, Zheng W, Seoane JA, Curtis C, Kenigsberg E, Wang J, Aguirre-Ghiso JA. ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung. Nat Cancer. 2022 Oct;3(10):1165-1180.

  • Li D, Yang J, Malik V, Huang Y, Huang X, Zhou H, Wang J. An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity. Nucleic Acids Res. 2022 Nov 28;50(21):12462-12479.

  • Li D, Yang J, Huang X, Zhou H, Wang J. eIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of stem cell pluripotency. Sci Adv. 2022 Apr;8(13).

  • Guallar D, Bi X*, Pardavila JA*, Huang X*, Saenz C, Shi X, Zhou H, Faiola F, Ding J, Haruehanroengra P, Yang F, Li D, Sanchez-Priego C, Saunders A, Pan F, Valdes VJ, Kelley K, Blanco MG, Chen L, Wang H, Sheng J, Xu M, Fidalgo M, Shen X, Wang J. RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells. Nat Genet. 2018 Mar;50(3):443-451. (*equal contribution)

  • Saunders A, Huang X, Fidalgo M, Reimer MH Jr, Faiola F, Ding J, Sánchez-Priego C, Guallar D, Sáenz C, Li D, Wang J. The SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency. Cell Rep. 2017 Feb 14;18(7):1713-1726.

  • Fidalgo M, Huang X, Guallar D, Sanchez-Priego C, Valdes VJ, Saunders A, Ding J, Wu WS, Clavel C, Wang J. Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States. Cell Stem Cell. 2016 Sep 1;19(3):355-69.

  • Ding J, Huang X, Shao N, Zhou H, Lee DF, Faiola F, Fidalgo M, Guallar D, Saunders A, Shliaha PV, Wang H, Waghray A, Papatsenko D, Sánchez-Priego C, Li D, Yuan Y, Lemischka IR, Shen L, Kelley K, Deng H, Shen X, Wang J. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. Cell Stem Cell. 2015 Jun 4;16(6):653-68.

  • Gingold JA, Fidalgo M, Guallar D, Lau Z, Sun Z, Zhou H, Faiola F, Huang X, Lee DF, Waghray A, Schaniel C, Felsenfeld DP, Lemischka IR, Wang J. A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming. Mol Cell. 2014 Oct 2;56(1):140-52.

2008 ~ 2013 (Student in UNMC): Cancer Genetics, Lymphoma, and Mass Spectrometry

  • Iqbal J*, Shen Y*, Huang X*, Liu Y, Wake L, Liu C, Deffenbacher K, Lachel CM, Wang C, Rohr J, Guo S, Smith LM, Wright G, Bhagavathi S, Dybkaer K, Fu K, Greiner TC, Vose JM, Jaffe E, Rimsza L, Rosenwald A, Ott G, Delabie J, Campo E, Braziel RM, Cook JR, Tubbs RR, Armitage JO, Weisenburger DD, Staudt LM, Gascoyne RD, McKeithan TW, Chan WC. Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma. Blood. 2015 Feb 12;125(7):1137-45. (*co-first)

  • Huang X, Meng B, Iqbal J, Ding BB, Perry AM, Cao W, Smith LM, Bi C, Jiang C, Greiner TC, Weisenburger DD, Rimsza L, Rosenwald A, Ott G, Delabie J, Campo E, Braziel RM, Gascoyne RD, Cook JR, Tubbs RR, Jaffe ES, Armitage JO, Vose JM, Staudt LM, McKeithan TW, Chan WC, Ye BH, Fu K. Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol. 2013 Dec 20;31(36):4520-8.

  • Huang X, Shen Y, Liu M, Bi C, Jiang C, Iqbal J, McKeithan TW, Chan WC, Ding SJ, Fu K. Quantitative proteomics reveals that miR-155 regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma. Am J Pathol. 2012 Jul;181(1):26-33.

  • Huang X, Huang L, Peng H, Guru A, Xue W, Hong SY, Liu M, Sharma S, Fu K, Caprez AP, Swanson DR, Zhang Z, Ding SJ. ISPTM: an iterative search algorithm for systematic identification of post-translational modifications from complex proteome mixtures. J Proteome Res. 2013 Sep 6;12(9):3831-42.

  • Huang X, Tian C, Liu M, Wang Y, Tolmachev AV, Sharma S, Yu F, Fu K, Zheng J, Ding SJ. Quantitative proteomic analysis of mouse embryonic fibroblasts and induced pluripotent stem cells using 16O/18O labeling. J Proteome Res. 2012 Apr 6;11(4):2091-102.

  • Huang X, Liu M, Nold MJ, Tian C, Fu K, Zheng J, Geromanos SJ, Ding SJ. Software for quantitative proteomic analysis using stable isotope labeling and data independent acquisition. Anal Chem. 2011 Sep 15;83(18):6971-9.

  • Huang X, Tolmachev AV, Shen Y, Liu M, Huang L, Zhang Z, Anderson GA, Smith RD, Chan WC, Hinrichs SH, Fu K, Ding SJ. UNiquant, a program for quantitative proteomics analysis using stable isotope labeling. J Proteome Res. 2011 Mar 4;10(3):1228-37.

  • Huang X, Shao L, Gong Y, Mao Y, Liu C, Qu H, Cheng Y. A metabonomic characterization of CCl4-induced acute liver failure using partial least square regression based on the GC/MS metabolic profiles of plasma in mice. J Chromatogr B. 2008 Jul 15;870(2):178-85.

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  • Rao E, Jiang C, Ji M, Huang X, Iqbal J, Lenz G, Wright G, Staudt LM, Zhao Y, McKeithan TW, Chan WC, Fu K. The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. Leukemia. 2012 May;26(5):1064-72.

  • Liu M, Hou J, Huang L, Huang X, Heibeck TH, Zhao R, Pasa-Tolic L, Smith RD, Li Y, Fu K, Zhang Z, Hinrichs SH, Ding SJ. Site-specific proteomics approach for study protein S-nitrosylation. Anal Chem. 2010 Sep 1;82(17):7160-8.

Copyright © 2025 Xin Huang Lab @UCLA

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